There is a popular notion that omeprazole and other PPIs may increase the risk of stomach cancer. If heartburn or GERD requires long-term omeprazole treatment, talk to a healthcare professional about alternative drugs, diets, or lifestyle choices to better manage the symptoms. Long-term use is only advised for people with rare medical conditions that cause hypersecretion of stomach acid. Keep in mind that omeprazole is only intended for short-term treatment of heartburn, GERD, and other gastrointestinal conditions. The reasons are unclear but are thought to possibly be due to increased food consumption when symptoms are better controlled. Significant weight gain has been linked with years-long use of omeprazole and other PPIs (proton pump inhibitors) to treat heartburn or GERD symptoms. Weight gain : Long-term use of omeprazole increases the risk of weight gain in patients with GERD.Over time, atrophic gastritis destroys the stomach lining and raises the risk of stomach cancer. Atrophic gastritis leads to vitamin B-12 deficiency, a condition that eventually causes anemia (a shortage of healthy red blood cells). Atrophic gastritis and low vitamin B – 12 : Chronic omeprazole use may also cause atrophic gastritis (swelling and irritation of the stomach lining).Low magnesium (hypomagnesemia) leads to several mild to serious consequences including heart rhythm problems or seizures. Low magnesium : Long-term omeprazole use can also lower magnesium levels in the body. More seriously but more rarely, omeprazole has also been associated with slow-growing tumors (carcinoids) in the duodenum, the first part of the small intestine, in patients with Zollinger-Ellision syndrome.
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